Roche: Gantenerumab discontinued in prodromal AD, MARIANNE not as good as hoped

NEUTRAL, Fair Value CHF302 (+5%)

News published on December Friday 19, 2014
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In two separate press releases, Roche today announce that (i) gantenerumab is being discontinued in prodromal Alzheimer’s disease (AD) based on the results of a pre-planned futility analysis and a recommendation by the DMC although it is moving forward in later stages of AD; (ii) the MARIANNE phase III whose primary endpoint was comparative PFS between Herceptin-based SoC, Kadcyla and Kadcyla/Perjeta delivers first data which show non-inferiority but not superiority which indeed is disappointing and could make inroads for new HER2+ therapies less easy for Roche.


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