Organizations are set to take a giant leap towards a vision of Industry 4.0 defined by hyperconnectivity, flexibility, and intelligence. This vision starts from planning and designing a product, a building or a plant and extends to engineering, simulation, building/production, and quality testing. The manufacturing plant is now a “product” too, but we are still a long way from the paradigm shift towards totally automated factories. Nonetheless, we believe smart factories are set to flourish in the next decade as the regionalization of production and the transition from mass production to mass customization drives more flexibility, autonomy, and efficiency in manufacturing plants. On the hardware front, the complexity of the underlying technologies, mainly sensing and AI, will continue to give birth to new and disruptive players, while we expect the software market to continue to consolidate.